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Contraindicated (one)pentobarbital decreases levels of vandetanib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Stay clear of coadministration with powerful CYP3A4 inducers; these medication lower exposure to vandetanib by approximately 40%.pentobarbital will lessen the level or effect of diclofenac by influencing hep

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